![]() However, only some of the patients with DM2 will develop these vascular complications while others, despite presenting the same risk factors, will not suffer cardiovascular events during the disease course. The advance of these vascular complications is determined by the presence of common risk factors in DM2 such as obesity, chronic hyperglycemia, insulin resistance, dyslipidemia and states of inflammation and oxidation, among others. ![]() Several studies reveal that DM2 is an independent risk factor in cardiovascular disease (CVD) development in both men and women 4, 5. Among the complications, chronic ischemia of lower limbs due to atherosclerotic processes is among the most frequent vascular problems in DM2 patients, with a prevalence of calcified plaques in the lower limbs that may reach 44.6% in this population 3. DM2 is associated with various complications, with cardiovascular disorders being one of the main causes of mortality in this disease 2. An increased incidence of DM2 cases is predicted worldwide, involving more than 300 million people in 2025 1. Diabetes mellitus type 2 (DM2) is a significant public health problem throughout the world which affects a large sector of the population.
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